Abstract | Background: Results: Our observations showed the efficacy of 2% moringin cream treatment in reducing clinical and histological disease score, as well as in alleviating neuropathic pain with consequent recovering of the hind limbs and response to mechanical stimuli. In particular, Western blot analysis and immunohistochemical evaluations revealed that 2% moringin cream was able to counteract the inflammatory cascade by reducing the production of pro-inflammatory cytokines (interleukin-17 and interferon-γ) and in parallel by increasing the expression of anti-inflammatory cytokine (interleukin-10). Interestingly, 2% moringin cream treatment was found to modulate the expression of voltage-gated ion channels (results focused on P2X7, Nav 1.7, Nav 1.8 KV4.2, and α2δ-1) as well as metabotropic glutamate receptors (mGluR5 and xCT) involved in neuropathic pain initiation and maintenance. Conclusions:
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Authors | Sabrina Giacoppo, Renato Iori, Placido Bramanti, Emanuela Mazzon |
Journal | Molecular pain
(Mol Pain)
2017 Jan-Dec
Vol. 13
Pg. 1744806917724318
ISSN: 1744-8069 [Electronic] United States |
PMID | 28741431
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- Ion Channels
- Isothiocyanates
- Plant Extracts
- moringin
- benzyl isothiocyanate
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Topics |
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Cytokines
(metabolism)
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
(drug therapy)
- Female
- Ion Channels
(drug effects)
- Isothiocyanates
(pharmacology)
- Mice, Inbred C57BL
- Multiple Sclerosis
(drug therapy)
- Neuralgia
(drug therapy)
- Plant Extracts
(pharmacology)
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