Abstract | BACKGROUND: Although oral contraceptives (OCs) are the most common treatment in women with polycystic ovary syndrome (PCOS), their effects and safety on the metabolic profiles of these patients are relatively unknown. In this meta-analysis the effects of the different durations (from 3months to 1year) of OC treatment using cyproterone acetate (CA) or third generation progestins on metabolic profile of patients with PCOS were assessed. MATERIALS AND METHODS: PubMed, Scopus, Google Scholar and ScienceDirect databases (2001-2015) were searched to identify clinical trials investigating the effects of OC containing CA or third generation progestins on metabolic profiles of women with PCOS. Both fixed and random effect models were used. Subgroup analyses were performed based on the progestin compounds used and on duration of treatment. RESULTS: CONCLUSIONS: The study shows that, in women with PCOS, OC use is associated with significant changes in lipid profiles, including elevation not only in HDL-C but also in TG and LDL-C. All OCs studied showed similar effects but with different timings, with products containing CA generally requiring more prolonged use to increase serum lipids. Instead, OC use does not affect body weight, BP or glucose levels, with only some minor increase of fasting insulin levels.
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Authors | Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Ali Kabir, Fereidoun Azizi, Enrico Carmina |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 73
Pg. 22-35
(08 2017)
ISSN: 1532-8600 [Electronic] United States |
PMID | 28732568
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- Contraceptives, Oral
- Insulin
- Progestins
- Cyproterone Acetate
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Topics |
- Blood Glucose
(drug effects)
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Clinical Trials as Topic
- Contraceptives, Oral
(chemistry, pharmacology)
- Cyproterone Acetate
(chemistry, pharmacology)
- Female
- Humans
- Insulin
(blood)
- Lipid Metabolism
(drug effects)
- Metabolome
(drug effects)
- Polycystic Ovary Syndrome
(metabolism)
- Progestins
(chemistry, pharmacology)
- Time Factors
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