Abstract | BACKGROUND AND AIMS: METHODS: 265 PAD patients were followed up for a median of 23 months, during which 18 people suffered a myocardial infarction. Fasting serum concentrations of 332 lipid species were measured via mass spectrometry and their association with incident myocardial infarction was assessed via Cox regression. Secondary analyses investigated prognostic potential of specific lipid species. RESULTS: Total serum concentrations of alkyl- phosphatidylcholine and alkenylphospatidylcholine ( plasmalogen) lipids were inversely associated with incident myocardial infarction after adjusting for multiple testing (hazards ratio (95% confidence intervals): 0.43 (0.24-0.74); p = 0.032; and 0.28 (0.14-0.56), p = 0.010, respectively). Specifically, 10 alkenylphosphatidylcholine species and 6 alkyl- phosphatidylcholine species were negatively associated with incident myocardial infarction after adjusting for traditional risk factors and correcting for multiple testing (hazards ratios ranging from 0.07 to 0.51, p < 0.05). Incorporation of serum phosphatidylcholine plasmalogen species PC(P-40:6) concentration within analyses designed to determine subsequent myocardial infarction incidence led to an improvement in predictive accuracy compared to traditional risk factors alone. CONCLUSIONS:
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Authors | Joseph V Moxon, Rhondda E Jones, Gerard Wong, Jacquelyn M Weir, Natalie A Mellett, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 263
Pg. 301-308
(08 2017)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 28728066
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Phosphatidylcholines
- Plasmalogens
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Topics |
- Aged
- Area Under Curve
- Biomarkers
(blood)
- Chromatography, Liquid
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
(blood, diagnosis, epidemiology)
- Odds Ratio
- Peripheral Arterial Disease
(blood, diagnosis, epidemiology)
- Phosphatidylcholines
(blood)
- Plasmalogens
(blood)
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Queensland
(epidemiology)
- ROC Curve
- Risk Factors
- Tandem Mass Spectrometry
- Time Factors
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