Carbon-ion radiotherapy for isolated para-aortic lymph node recurrence from colorectal cancer.

Abstract

BACKGROUND:

The safety and effectiveness of carbon-ion radiotherapy (CIRT) for isolated para-aortic lymph node (PALN) metastasis was evaluated retrospectively.

METHODS:

CIRT for isolated PALN metastasis from CRC was performed in 34 cases from June 2006 to August 2015 in our institute. A median dose of 52.8 Gy(RBE) (range, 48-52.8 Gy(RBE)) was delivered with a median daily dose of 4.4 Gy(RBE) (range, 4.0-4.4 Gy(RBE)).

RESULTS:

The median follow-up duration for all patients was 24.4 months (range, 7-82.8 months). There were 13 cases (38.2%) who achieved complete response after treatment. The local control rates at 2 and 3 years were 70.1% and 70.1%, respectively. The overall survival rates at 2 and 3 years were 83.3% and 63.0%, respectively. The 3-year survival rates for Stage I-III were 68.7%, while those for Stage IV was 0%. The overall survival of cases with rectal cancer or with high CA19-9 values pre-CIRT tended to be worse. The median survival period was 41.7 months. Twelve of the 34 patients survived for more than 3 years. There were no adverse effects of Grade 3 or higher.

CONCLUSIONS:

CIRT for isolated PALN recurrence after curative resection for CRC appears effective and safe, and it is considered a promising therapy.

• Authors: Yuka Isozaki, Shigeru Yamada, Shohei Kawashiro, Shigeo Yasuda, Naomi Okada, Daniel Ebner, Hiroshi Tsuji, Tadashi Kamada, Hisahiro Matsubara
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 116 Issue 7 Pg. 932-938 (Dec 2017) ISSN: 1096-9098 [Electronic] United States
• PMID: 28727901 (Publication Type: Journal Article)
• Copyright: © 2017 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Aged, 80 and over
• Colorectal Neoplasms (pathology, radiotherapy)
• Female
• Heavy Ion Radiotherapy (methods)
• Humans
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (pathology, radiotherapy)
• Retrospective Studies