Abstract | BACKGROUND: METHODS: Clinical Benefit Rates (CBR) and deaths from clinical trials of endocrine agents were meta-analyzed. Summary estimates of CBR (SCBR) and Odd Ratio for death (SOR) were calculated according with type of drug, ER and PgR status, platinum resistance, line of therapy, tumor grade and tamoxifen dose. RESULTS: Fifty-three trials in 2490 patients were analyzed. Overall, SCBR was 41% (95%CI, 0.34-0.48) for any endocrine treatment, 43% (95%CI, 0.30-0.56) for tamoxifen, 39% (95%CI, 0.29-0.50) for aromatase inhibitors and 37% (95%CI, 0.26-0.48) for progestins. The SCBR for ER+ and/or PgR+ tumors was 46% (95%CI, 0.34-0.57) versus 37% (95%CI, 0.27-0.48) in tumors with unknown receptors and 55% in platinum sensitive (95%CI, 0.28-0.80) versus 40% (95%CI, 0.29-0.51) in platinum resistant tumors The SOR for death calculated from 6 out of 9 randomized clinical trials (RCTs) showed a reduced mortality with endocrine therapy (SOR=0.69, 95%CI, 0.50-0.97), with a possible tendency for a greater effect in first line and low grade tumors. The overall quality of the RCTs was low. CONCLUSIONS: The activity of endocrine therapy in advanced EOC is worth considering and seems to support large properly designed randomized trials in the first treatment of hormone sensitive EOC.
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Authors | Laura Paleari, Sara Gandini, Nicoletta Provinciali, Matteo Puntoni, Nicoletta Colombo, Andrea DeCensi |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 146
Issue 3
Pg. 504-513
(09 2017)
ISSN: 1095-6859 [Electronic] United States |
PMID | 28705409
(Publication Type: Journal Article, Meta-Analysis, Review)
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Copyright | Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents, Hormonal
- Aromatase Inhibitors
- Platinum Compounds
- Progestins
- Receptors, Estrogen
- Receptors, Progesterone
- Tamoxifen
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Topics |
- Antineoplastic Agents, Hormonal
- Aromatase Inhibitors
(therapeutic use)
- Carcinoma, Ovarian Epithelial
- Clinical Trials as Topic
- Drug Resistance, Neoplasm
- Female
- Humans
- Neoplasm Grading
- Neoplasms, Glandular and Epithelial
(chemistry, drug therapy, mortality, pathology)
- Ovarian Neoplasms
(chemistry, drug therapy, mortality, pathology)
- Platinum Compounds
- Progestins
(therapeutic use)
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Survival Rate
- Tamoxifen
(administration & dosage, therapeutic use)
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