Independent and opposite associations of serum levels of omentin-1 and adiponectin with increases of glycaemia and incident type 2 diabetes in an older population: KORA F4/FF4 study.

Abstract

OBJECTIVE:

Cross-sectional studies found that higher levels of the novel adipokine omentin-1 were associated with higher adiponectin and lower levels of risk factors for type 2 diabetes, but its relevance for incident type 2 diabetes is currently not understood. Therefore this study investigated whether serum omentin-1 was associated with changes in glycaemia and incident type 2 diabetes independently of adiponectin.

DESIGN AND METHODS:

The study was based on participants aged 62-81 years from the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort. Associations of baseline serum levels of omentin-1 and adiponectin with changes in glycaemia were assessed in 471 non-diabetic participants, and associations between both adipokines and incident type 2 diabetes were assessed in 76 cases and 430 non-cases (follow-up time 6.5 years). Multivariable linear and logistic regression models were adjusted for multiple potential confounders.

RESULTS:

Higher serum levels of omentin-1 were associated with increases in fasting glucose, 2-h glucose and HbA1c (all P < 0.001) and with incident type 2 diabetes (adjusted odds ratio (OR) (95% CI): 1.40 (1.03; 1.90) per s.d. of log2-transformed omentin-1; P = 0.032). These associations were independent from adiponectin levels, which showed associations with changes in glycaemia and risk of type 2 diabetes in the opposite direction. We found no statistically significant interactions of omentin-1 with adiponectin or sex in the association with incident type 2 diabetes (all P > 0.1).

CONCLUSIONS:

Systemic levels of omentin-1 were positively associated with increases in glycaemia and incident type 2 diabetes in this older population. These associations were independent of potential confounders including adiponectin.

• Authors: Christian Herder, Julia M Kannenberg, Corinna Niersmann, Cornelia Huth, Maren Carstensen-Kirberg, Clemens Wittenbecher, Matthias Schulze, Matthias Blüher, Wolfgang Rathmann, Annette Peters, Michael Roden, Christa Meisinger, Barbara Thorand
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 177 Issue 4 Pg. 277-286 (Oct 2017) ISSN: 1479-683X [Electronic] England
• PMID: 28679518 (Publication Type: Journal Article)
• Copyright: © 2017 European Society of Endocrinology.

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Biomarkers
• Blood Glucose
• Cytokines
• GPI-Linked Proteins
• ITLN1 protein, human
• Lectins

Topics

• Adiponectin (blood)
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Cross-Sectional Studies
• Cytokines (blood)
• Diabetes Mellitus, Type 2 (blood, diagnosis, epidemiology)
• Female
• Follow-Up Studies
• GPI-Linked Proteins (blood)
• Germany (epidemiology)
• Glycemic Index (physiology)
• Humans
• Incidence
• Lectins (blood)
• Male
• Middle Aged
• Population Surveillance (methods)
• Prospective Studies