The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Urinary Bladder Cancer Patients.

Abstract

BACKGROUND:

The aim of this study was to investigate a potential role of alcohol dehydrogenase and aldehyde dehydrogenase as tumor markers for urinary bladder cancer.

MATERIALS AND METHODS:

Serum samples were obtained from 41 patients with bladder cancer and 52 healthy individuals. Class III and IV of ADH and total ADH activity were measured by the photometric method. For measurement of class I and II ADH and ALDH activity, the fluorometric method was employed.

RESULTS:

Significantly higher total activity of ADH was found in sera of both, low-grade and high-grade bladder cancer patients. The diagnostic sensitivity for total ADH activity was 81.5%, specificity 98.1%, positive (PPV) and negative (NPV) predictive values were 97.4% and 92.3% respectively. Area under ROC curve for total ADH activity was 0.848.

CONCLUSION:

A potential role of total ADH activity as a marker for bladder cancer, is herein proposed.

• Authors: Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
• Journal: Anticancer research (Anticancer Res) Vol. 37 Issue 7 Pg. 3537-3541 (07 2017) ISSN: 1791-7530 [Electronic] Greece
• PMID: 28668843 (Publication Type: Journal Article)
• Copyright: Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• Isoenzymes
• Alcohol Dehydrogenase
• Aldehyde Dehydrogenase

Topics

• Aged
• Aged, 80 and over
• Alcohol Dehydrogenase (blood)
• Aldehyde Dehydrogenase (blood)
• Biomarkers, Tumor (blood)
• Female
• Humans
• Isoenzymes (blood)
• Male
• Middle Aged
• Urinary Bladder (pathology)
• Urinary Bladder Neoplasms (blood, diagnosis)