Abstract | OBJECTIVES: For patients with unresectable or metastatic thymic epithelial neoplasms, few therapy options are available and outcomes are poor. This case series demonstrates that the combination of capecitabine and celecoxib may be a promising therapeutic option for these patients. MATERIALS AND METHODS: The current report describes the outcomes of 5 patients with thymic neoplasms treated on a drug-drug interaction study of capecitabine and celecoxib in patients with advanced solid malignancies (NCT01705106) conducted at the University of Chicago, plus a sixth patient treated with the same regimen outside of the protocol. RESULTS: Six patients with thymic neoplasms were treated with capecitabine 1000 mg/m twice daily and celecoxib 200 mg twice daily, day 1 to day 14 on a 21-day cycle. This included 3 patients with thymic carcinoma, 1 with thymic neuroendocrine tumor, and 2 with thymomas. Objective response rates were noted in 3 of 6 patients. Two of the 3 thymic carcinoma patients had complete responses, and the third had a partial response. Best response for the other patients included stable disease for both thymoma patients and progressive disease for the thymic neuroendocrine patient. Other than grade 3 palmar-plantar erythrodysesthesia, which developed in 4 of 6 patients and required dose reductions, the regimen was well tolerated. CONCLUSIONS:
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Authors | Kevin Wood, Elizabeth Byron, Linda Janisch, Ravi Salgia, Manish R Sharma |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 41
Issue 10
Pg. 963-966
(10 2018)
ISSN: 1537-453X [Electronic] United States |
PMID | 28654574
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Capecitabine
(administration & dosage)
- Celecoxib
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy, pathology)
- Prognosis
- Survival Rate
- Thymus Neoplasms
(drug therapy, pathology)
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