IgMk paraprotein from gammopathy patient can bind to cardiolipin and interfere with coagulation assay: a case report.

Abstract

BACKGROUND:

The monoclonal gammopathies are a group of plasma-cell proliferative disorders characterized by the secretion of monoclonal immunoglobulin (M protein or paraprotein). Some rare cases have revealed the specific affinity of paraprotein as autoantibody. Here we report a patient with monoclonal gammopathy of undetermined significance (MGUS) accompanied by a remarkable increase of anticardiolipin antibody (aCL) and an extensively decreased coagulation factor activity, however, without any clinical signs of antiphospholipid syndrome (APS) and bleeding.

RESULTS:

Our further investigation indicated that IgMκ paraprotein of this patient possessed an antibody activity against phospholipids so as to bind to cardiolipin and interfere with coagulation assay in vitro.

CONCLUSIONS:

This case might be indicative that an abnormality of coagulation tests, disturbed by IgMκ paraprotein, does not predict a risk of bleeding in this patient.

• Authors: Xin-Yao Wu, Yu-Feng Yin, Jia-Lin Teng, Li-Wei Zhang, Cheng-de Yang
• Journal: BMC immunology (BMC Immunol) Vol. 18 Issue 1 Pg. 32 (06 23 2017) ISSN: 1471-2172 [Electronic] England
• PMID: 28645246 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Cardiolipins
• Immunoglobulin M
• Immunoglobulin kappa-Chains

Topics

• Autoantibodies (metabolism)
• Blood Coagulation
• Blood Coagulation Tests (methods, standards)
• Cardiolipins (metabolism)
• Diagnostic Errors (prevention & control)
• Humans
• Immunoglobulin M (genetics, metabolism)
• Immunoglobulin kappa-Chains (genetics, metabolism)
• Male
• Middle Aged
• Paraproteinemias (blood, diagnosis)
• Protein Binding