The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.

Abstract

Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.

• Authors: Minna K Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, Ruin Moaddel
• Journal: Marine drugs (Mar Drugs) Vol. 15 Issue 6 (Jun 21 2017) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 28635654 (Publication Type: Journal Article)

Chemical References

• Polysaccharides
• fucoidan
• Sirtuins

Topics

• Fucus (chemistry)
• Humans
• Mass Spectrometry (methods)
• Phaeophyceae (chemistry)
• Polysaccharides (chemistry, pharmacology)
• Seaweed (chemistry)
• Sirtuins (metabolism)