Boric acid gel as local drug delivery in the treatment of class II furcation defects in chronic periodontitis: a randomized, controlled clinical trial.

Abstract

AIM:

Boric acid (BA) exhibits antibacterial, anti-inflammatory, as well as osteoblastic, activity. The aim of the present study was to explore the efficacy of 0.75% BA gel as a local drug-delivery system in adjunct to scaling and root planing (SRP) for the treatment of class II furcation defects in comparison with placebo gel.

METHODS:

A total of 48 mandibular class II furcation defects were randomized and treated with either 0.75% BA gel or placebo gel. Clinical parameters were recorded at baseline, 3 months, and 6 months, while radiographic parameters were recorded at baseline and 6 months.

RESULTS:

Greater mean probing depth reduction and mean relative vertical and horizontal clinical attachment level gain were shown to be greater in group 1 than in group 2 at 3 and 6 months. Furthermore, a significantly greater mean percentage of bone fill was found in group 1 (16.98%±1.03%) than in the placebo (2.86%±0.92%) at 6 months.

CONCLUSION:

The .75% BA group showed significant improvement in clinical parameters compared to placebo gel as an adjunct to SRP. This implies an alternative for treatment of class II furcation.

• Authors: Sandeep Singhal, Avani Raju Pradeep, Dharmendra Kanoriya, Shruti Garg, Vibhuti Garg
• Journal: Journal of investigative and clinical dentistry (J Investig Clin Dent) Vol. 9 Issue 1 (Feb 2018) ISSN: 2041-1626 [Electronic] Australia
• PMID: 28631896 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2017 John Wiley & Sons Australia, Ltd.

Chemical References

• Boric Acids
• Gels

Topics

• Administration, Oral
• Adult
• Bone Regeneration (drug effects)
• Boric Acids (administration & dosage, therapeutic use)
• Chronic Periodontitis (drug therapy)
• Dental Plaque Index
• Dental Scaling
• Drug Delivery Systems (methods)
• Female
• Furcation Defects (diagnostic imaging, drug therapy)
• Gels
• Humans
• Male
• Mandible
• Middle Aged
• Osteoblasts (drug effects)
• Periodontal Index
• Periodontal Pocket (drug therapy)
• Root Planing
• Treatment Outcome