Effects of different doses of triazolam in the middle-of-the-night insomnia: a double-blind, randomized, parallel group study.

Abstract

It has been reported that insomnia characterized by difficulty returning to sleep following a nocturnal awakening, otherwise defined as the middle-of-the-night (MOTN) insomnia, is a common form of insomnia in adults with growing prevalence by increasing age. The aim of this study is to evaluate the efficacy and safety of different dosages of triazolam in insomnia patients when taken after a MOTN awakening with difficulty returning to sleep. In this double-blind, randomized, parallel group study, 24 patients (mean age 41.00 ± 10.40, 10 female and 14 male) affected by MOTN insomnia were enrolled and randomized into three groups according to different dosages of triazolam: group A (0.0625 mg), group B (0.125 mg), and group C (0.250 mg). A significant increment of total sleep time, sleep efficiency and a reduction of wake after sleep onset, number of awakening and non-REM sleep stage 1 was observed in T1 (triazolam) in comparison to T0 (placebo) by means of polysomnographic recording, irrespective of dosage. After 2 weeks of the treatment, insomnia severity significantly improved in all three groups in comparison to baseline without diurnal residual effects. This study demonstrates that low dose of triazolam objectively and subjectively improves the sleep of patients having MOTN insomnia.

• Authors: Luigi Ferini Strambi, Sara Marelli, Marco Zucconi, Andrea Galbiati, Giovanni Biggio
• Journal: Journal of neurology (J Neurol) Vol. 264 Issue 7 Pg. 1362-1369 (Jul 2017) ISSN: 1432-1459 [Electronic] Germany
• PMID: 28584913 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Hypnotics and Sedatives
• Triazolam

Topics

• Adult
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Humans
• Hypnotics and Sedatives (administration & dosage)
• Male
• Middle Aged
• Polysomnography
• Psychomotor Performance (drug effects)
• Severity of Illness Index
• Sleep (drug effects)
• Sleep Initiation and Maintenance Disorders (drug therapy, physiopathology)
• Treatment Outcome
• Triazolam (administration & dosage)
• Young Adult