Gunnilactams A-C, Macrocyclic Tetralactams from the Mycelial Culture of the Entomogenous Fungus Paecilomyces gunnii.

Abstract

Three novel macrocyclic tetralactams, gunnilactam A (1), gunnilactam B (2), and gunnilactam C (3), were isolated from the submerged fermentation broth of Paecilomyces gunnii, an entomogenous fungus identified as the anamorph of Cordyceps gunnii. Their structures were determined using NMR data, HREIMS, and single-crystal X-ray crystallography. Gunnilactam A exhibited selective cytotoxic activity against human prostate cancer C42B cells with an IC50 value of 5.4 μM.

• Authors: Yongbiao Zheng, Jiyan Zhang, Liufeng Wei, Mianmian Shi, Jifeng Wang, Jianzhong Huang
• Journal: Journal of natural products (J Nat Prod) Vol. 80 Issue 6 Pg. 1935-1938 (06 23 2017) ISSN: 1520-6025 [Electronic] United States
• PMID: 28562046 (Publication Type: Journal Article)

Chemical References

• Lactams
• Lactams, Macrocyclic
• Macrocyclic Compounds
• gunnilactam A
• gunnilactam B
• gunnilactam C
• tetralactam macrocycle

Topics

• Cordyceps (chemistry)
• Crystallography, X-Ray
• Humans
• Lactams
• Lactams, Macrocyclic (chemistry, isolation & purification)
• Macrocyclic Compounds
• Molecular Structure
• Paecilomyces (chemistry)