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High virulence of methicillin resistant Staphylococcus aureus ST30-SCCmecIVc-spat019, the dominant community-associated clone in Argentina.

Abstract
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa. A representative strain of ST30 lineage has a more aggressive behavior in animal models of infection and expresses higher level of Fibronectin binding protein A coding gene, which could enhance the bacterial invasion capacity.
AuthorsSilvina Fernandez, Camila Ledo, Santiago Lattar, Mariángeles Noto Llana, Andrea Mendoza Bertelli, Sabrina Di Gregorio, Daniel O Sordelli, Marisa I Gómez, Marta E Mollerach
JournalInternational journal of medical microbiology : IJMM (Int J Med Microbiol) Vol. 307 Issue 4-5 Pg. 191-199 (Jun 2017) ISSN: 1618-0607 [Electronic] Germany
PMID28549830 (Publication Type: Journal Article)
CopyrightCopyright © 2017. Published by Elsevier GmbH.
Chemical References
  • Adhesins, Bacterial
  • Bacterial Proteins
  • Virulence Factors
  • fibronectin-binding proteins, bacterial
Topics
  • Adhesins, Bacterial (genetics, metabolism)
  • Animals
  • Argentina
  • Bacterial Proteins (genetics, metabolism)
  • Colony Count, Microbial
  • Cross Infection (microbiology)
  • Disease Models, Animal
  • Female
  • Methicillin-Resistant Staphylococcus aureus (genetics, isolation & purification, pathogenicity)
  • Mice
  • Mice, Inbred BALB C
  • Multicenter Studies as Topic
  • Rats
  • Rats, Wistar
  • Respiratory Tract Infections (microbiology)
  • Staphylococcal Skin Infections (microbiology)
  • Virulence Factors (genetics)

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