Abstract |
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa. A representative strain of ST30 lineage has a more aggressive behavior in animal models of infection and expresses higher level of Fibronectin binding protein A coding gene, which could enhance the bacterial invasion capacity.
|
Authors | Silvina Fernandez, Camila Ledo, Santiago Lattar, Mariángeles Noto Llana, Andrea Mendoza Bertelli, Sabrina Di Gregorio, Daniel O Sordelli, Marisa I Gómez, Marta E Mollerach |
Journal | International journal of medical microbiology : IJMM
(Int J Med Microbiol)
Vol. 307
Issue 4-5
Pg. 191-199
(Jun 2017)
ISSN: 1618-0607 [Electronic] Germany |
PMID | 28549830
(Publication Type: Journal Article)
|
Copyright | Copyright © 2017. Published by Elsevier GmbH. |
Chemical References |
- Adhesins, Bacterial
- Bacterial Proteins
- Virulence Factors
- fibronectin-binding proteins, bacterial
|
Topics |
- Adhesins, Bacterial
(genetics, metabolism)
- Animals
- Argentina
- Bacterial Proteins
(genetics, metabolism)
- Colony Count, Microbial
- Cross Infection
(microbiology)
- Disease Models, Animal
- Female
- Methicillin-Resistant Staphylococcus aureus
(genetics, isolation & purification, pathogenicity)
- Mice
- Mice, Inbred BALB C
- Multicenter Studies as Topic
- Rats
- Rats, Wistar
- Respiratory Tract Infections
(microbiology)
- Staphylococcal Skin Infections
(microbiology)
- Virulence Factors
(genetics)
|