Abstract | AIMS: METHODS: A total of 25 eyes of 25 consecutive T1DM patients without signs of DR were prospectively recruited and compared to 25 healthy subjects (control eyes). All patients underwent OCT-A (CIRRUS HD-OCT model 5000, Carl Zeiss Meditec, Dublin, CA) and structural OCT. Qualitative and quantitative analyses with vessel density were performed on OCT-A images in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris for all patients. RESULTS: By means of OCT-A, a rarefaction of the perifoveal capillary network in SCP was detected in 7 out of 25 eyes. No significant difference was found in FAZ area of both SCP and DCP comparing diabetic and control groups. By analyzing the DCP, diabetic eyes revealed a significant decreased vessel density compared to control eyes [0.464 ± 0.016 and 0.477 ± 0.014, respectively (p = 0.005)]. Instead, no significant difference was found in the vessel density of all-retina plexus, SCP and choriocapillaris. By RFNL and GCL thickness analysis, no significant differences were disclosed between diabetics and healthy subjects. CONCLUSIONS: We demonstrated the ability of OCT-A to disclose early vascular alterations in patients with T1DM diagnosed as without any signs of DR on the basis of fundus biomicroscopy. Our results also suggest that microvascular changes could precede detectable damage of diabetic neuroretinopathy.
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Authors | Adriano Carnevali, Riccardo Sacconi, Eleonora Corbelli, Livia Tomasso, Lea Querques, Gianpaolo Zerbini, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques |
Journal | Acta diabetologica
(Acta Diabetol)
Vol. 54
Issue 7
Pg. 695-702
(Jul 2017)
ISSN: 1432-5233 [Electronic] Germany |
PMID | 28474119
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Angiography
(methods)
- Diabetes Mellitus, Type 1
(complications, diagnosis, pathology)
- Diabetic Retinopathy
(diagnosis)
- Female
- Fluorescein Angiography
- Fundus Oculi
- Humans
- Male
- Predictive Value of Tests
- Retina
(diagnostic imaging)
- Retinal Ganglion Cells
(pathology, ultrastructure)
- Retinal Neurons
(pathology, ultrastructure)
- Retinal Vessels
(diagnostic imaging)
- Tomography, Optical Coherence
- Young Adult
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