Abstract | BACKGROUND: Lower albumin- globulin ratio (AGR) is associated with increased mortality in several cancers. However, no studies have evaluated the relationship between the AGR and prognostic outcome in esophageal cancer (EC) patients. METHODS: RESULTS: A lower AGR was significantly associated with tumor progression. The CEA level was an independent predictor for overall survival (OS) and disease-free survival (DFS). The AGR and CEA combination was identified as a feasible indicator of poor prognosis and early recurrence. Among EC patients without lymph node metastasis, those with lower AGR had poorer DFS and OS than those with higher AGR. CONCLUSION: AGR was identified as a significant predictor of OS and DFS in EC patients. Among EC patients without lymph node metastasis, AGR may help identify candidates who might benefit from more intensive adjuvant therapy.
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Authors | Satoshi Oki, Yuji Toiyama, Yoshinaga Okugawa, Tadanobu Shimura, Masato Okigami, Hiromi Yasuda, Hiroyuki Fujikawa, Yoshiki Okita, Shigeyuki Yoshiyama, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki |
Journal | American journal of surgery
(Am J Surg)
Vol. 214
Issue 5
Pg. 891-898
(Nov 2017)
ISSN: 1879-1883 [Electronic] United States |
PMID | 28460738
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Esophageal Neoplasms
(blood, mortality, surgery)
- Female
- Globulins
(analysis)
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(epidemiology)
- Preoperative Period
- Prognosis
- Serum Albumin
(analysis)
- Survival Rate
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