Modulation of Myostatin/Hepatocyte Growth Factor Balance by Different Hemodialysis Modalities.

Abstract

Background. In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels. Methods. We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF). Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared. Results. Ten patients and six controls (C) were evaluated. In any experimental condition myostatin and HGF levels were higher in HD than in C. At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated (r  -0.65, p < 0.05), myostatin serum levels inversely correlated with transferrin (r  -0.73, p < 0.05), and HGF levels that resulted positively correlated with BMI (r 0.67, p < 0.05). Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, p < 0.05). Conclusions. Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.

• Authors: Pasquale Esposito, Edoardo La Porta, Marta Calatroni, Maria Antonietta Grignano, Samantha Milanesi, Daniela Verzola, Yuri Battaglia, Marilena Gregorini, Carmelo Libetta, Giacomo Garibotto, Teresa Rampino
• Journal: BioMed research international (Biomed Res Int) Vol. 2017 Pg. 7635459 ( 2017) ISSN: 2314-6141 [Electronic] United States
• PMID: 28459069 (Publication Type: Journal Article)

Chemical References

• Bicarbonates
• HGF protein, human
• MSTN protein, human
• Myostatin
• Hepatocyte Growth Factor

Topics

• Aged
• Bicarbonates
• Cross-Over Studies
• Female
• Hemodiafiltration (methods, statistics & numerical data)
• Hepatocyte Growth Factor (blood, metabolism)
• Humans
• Male
• Middle Aged
• Myostatin (blood, metabolism)
• Prospective Studies