Saliva and plasma levels of cardiac-related biomarkers in post-myocardial infarction patients.

Abstract

AIM:

To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers.

MATERIALS AND METHODS:

Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA.

RESULTS:

The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15.

CONCLUSION:

Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.

• Authors: Nilminie Rathnayake, Kåre Buhlin, Barbro Kjellström, Bjorn Klinge, Christian Löwbeer, Anna Norhammar, Lars Rydén, Timo Sorsa, Taina Tervahartiala, Anders Gustafsson, PAROKRANK Steering Committee
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 44 Issue 7 Pg. 692-699 (Jul 2017) ISSN: 1600-051X [Electronic] United States
• PMID: 28453865 (Publication Type: Journal Article)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• Cystatin C
• GDF15 protein, human
• Growth Differentiation Factor 15

Topics

• Biomarkers (metabolism)
• Case-Control Studies
• Cystatin C (metabolism)
• Enzyme-Linked Immunosorbent Assay
• Female
• Growth Differentiation Factor 15 (metabolism)
• Humans
• Male
• Middle Aged
• Myocardial Infarction (metabolism)
• Saliva (chemistry)