Five-Year Follow-Up on Transplanted Organs From Donors After Brain Death After Acute Stroke.

Abstract

OBJECTIVES:

Efficient intensive care donor management can help alleviate the shortage of organs for transplant. The aim of this study was to investigate the efficiency of management of donors after brain death from our neurointensive care unit.

MATERIALS AND METHODS:

We conducted a prospective observational 5-year follow-up on 29 transplanted organs from 14 brain-dead donors after acute stroke (7 subarachnoid and 4 intracerebral hemorrhages, 3 ischemic strokes). Mean age of donors was 56.2 ± 8.70 years, and mean number of days of artificial ventilation was 5.0 ± 3.84. We transplanted 27 kidneys and 2 livers to 29 patients with mean age of 55.3 ± 9.76 years. No hearts or lungs were transplanted from these donors.

RESULTS:

Of the 27 patients who underwent kidney transplant, 21 patients (78%) lived 5 years; of those, 17 patients (63%) had functional grafts. One patient (4%) had a primary afunctional graft, and 3 patients (11%) had graft rejection (at 3, 15, and 41 mo). Six patients (22%) died after kidney transplant, with 1 patient in this group having a functional graft, 1 patient having a primary afunctional graft, and 4 patients (15%) having graft rejection (at 1, 12, 44, and 56 mo). The 2 patients with liver transplants lived 5 years with functional grafts.

CONCLUSIONS:

The 5-year follow-up showed that organs from 14 brain-dead donors improved and saved 19 lives, with 17 patients receiving kidney transplants and 2 patients receiving liver transplants. Another 7 patients had only partially improved quality of life.

• Authors: Vera Spatenkova, Eva Pokorna, Petr Suchomel
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 15 Issue 4 Pg. 445-447 (Aug 2017) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 28447929 (Publication Type: Journal Article, Observational Study)

Topics

• Adult
• Aged
• Brain Death (diagnosis)
• Brain Ischemia (diagnosis, mortality)
• Cause of Death
• Cerebral Hemorrhage (diagnosis, mortality)
• Donor Selection
• Female
• Follow-Up Studies
• Graft Rejection (etiology)
• Graft Survival
• Humans
• Male
• Middle Aged
• Organ Transplantation (adverse effects, methods, mortality)
• Primary Graft Dysfunction (etiology)
• Prospective Studies
• Quality of Life
• Stroke (diagnosis, mortality)
• Subarachnoid Hemorrhage (diagnosis, mortality)
• Time Factors
• Tissue Donors (supply & distribution)
• Treatment Outcome