A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk.

Abstract

BACKGROUND:

Previous studies suggest that a stable end-product of prostaglandin E2, the urinary metabolite PGE-M, is associated with colorectal cancer, and 1 study of relatively small sample size found an association with gastric cancer among women. In the present study we further investigate the PGE-M, Helicobacter pylori, and gastric cancer association.

METHODS:

The present analysis included 359 prospectively ascertained gastric cancer cases and 700 individually matched controls from the Shanghai Women's and Men's Health Studies. Urinary PGE-M was measured by a liquid chromatography/tandem mass spectrometric method. Seropositivity to 15 H. pylori recombinantly expressed fusion proteins was detected by H. pylori multiplex serology.

RESULTS:

Adjusting for H. pylori, increasing PGE-M was associated with higher risk of gastric cancer (quartile 4 vs 1: odds ratio [OR], 1.76 [95% confidence interval {CI}, 1.17-2.66], Ptrend = .004). This association remained after excluding those diagnosed within 2 years from sample collection (OR, 1.73 [95% CI, 1.12-2.65], Ptrend = .007). However it was no longer present among individuals with 10 or more years of follow-up (2-4.9 years: OR, 3.15 [95% CI, 1.11-8.91]; 5-9.9 years: OR, 2.23 [95% CI, 1.22-4.06]; ≥10 years: OR, 0.73 [95% CI, .31-1.70]). Compared to H. pylori-negative individuals with below-median PGE-M levels, H. pylori-positive individuals with above-median PGE-M levels had a 5-fold increase in the odds of gastric cancer (OR, 5.08 [95% CI, 2.47-10.43]).

CONCLUSIONS:

In China, higher PGE-M levels may indicate an increased risk of gastric cancer independent of the risk conferred by H. pylori infection status, particularly for cancers diagnosed within 10 years of sample collection.

• Authors: Tianyi Wang, Hui Cai, Wei Zheng, Angelika Michel, Michael Pawlita, Ginger Milne, Yong-Bing Xiang, Yu-Tang Gao, Hong-Lan Li, Nathaniel Rothman, Qing Lan, Xiao-Ou Shu, Meira Epplein
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 64 Issue 10 Pg. 1380-1386 (May 15 2017) ISSN: 1537-6591 [Electronic] United States
• PMID: 28402440 (Publication Type: Journal Article)
• Copyright: © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Prostaglandins
• Recombinant Fusion Proteins
• 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid

Topics

• Adult
• Aged
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (blood, immunology)
• Case-Control Studies
• China (epidemiology)
• Chromatography, Liquid
• Cohort Studies
• Female
• Follow-Up Studies
• Helicobacter Infections (blood, complications, immunology, urine)
• Helicobacter pylori (immunology, isolation & purification)
• Humans
• Inflammation (microbiology)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Prospective Studies
• Prostaglandins (urine)
• Recombinant Fusion Proteins (immunology)
• Risk Factors
• Serology
• Stomach Neoplasms (epidemiology, etiology, microbiology)
• Tandem Mass Spectrometry