Higher disappearance rate of anti-HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine.

Abstract

BACKGROUND & AIM:

The aim of this study was to compare the long-term efficacy of infant recombinant yeast hepatitis B vaccine (Recombinant group) and infant plasma-derived one (Plasma group) in Taiwanese freshers.

METHODS:

Recruited were a total of 38 377 freshmen who underwent university entrance health examinations from 2003 to 2015. Subjects were assigned into two groups-plasma type and recombinant type, according to the national neonatal hepatitis B immunization program. The seroprevalences of hepatitis B surface antigen, antibody against hepatitis B surface antigen, and antibody against hepatitis B core antigen in each group and gender were calculated. Multivariate logistic regression analysis was performed to compare the efficacy of two groups.

RESULTS:

The HBsAg-positive rates in the plasma group and recombinant group were 1.5% and 0.3% respectively. The anti-HBs positive rates were 43.6% and 30.9%. The hepatitis B viral natural infection rates were 3.6% and 1.3%. Taking those who were born in July 1986-April 1992 as baseline group after adjustment for gender and age at hepatitis B markers checkup time, the efficacy of recombinant group in decreasing HBsAg positive rate, and decreasing hepatitis B virus natural infection rate was 71.0% (95% C.I.: 59.0-79.0%, P<.001) and 65.0% (95% C.I. 58.0-71.0%, P<.001) respectively. On the contrary, the seroprevalence of anti-HBs positive rate in recombinant group was 39.0% (95% C.I.: 36.0-42.0%, P<.001) lower than that of plasma group. (P<.001).

CONCLUSION:

Higher disappearance rate of anti-HBs was noted in recombinant group than in plasma group when the subjects reached their youth and young adulthood in Taiwan.

• Authors: Shu-Hua Hsu, An-Hsuan Chih, Yi-Chin Lee, Kuo-Chin Huang, Chyi-Feng Jan
• Journal: Liver international : official journal of the International Association for the Study of the Liver (Liver Int) Vol. 37 Issue 12 Pg. 1780-1787 (12 2017) ISSN: 1478-3231 [Electronic] United States
• PMID: 28374906 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Antigens
• Hepatitis B Vaccines
• Vaccines, Synthetic

Topics

• Adolescent
• Female
• Hepatitis B Antibodies (blood)
• Hepatitis B Antigens (blood, immunology)
• Hepatitis B Vaccines
• Humans
• Infant
• Infant, Newborn
• Male
• Retrospective Studies
• Vaccination (statistics & numerical data)
• Vaccines, Synthetic
• Young Adult