Abstract | BACKGROUND: Recent studies have shown a potential role of RNA-binding proteins (RBPs) in a variety of biological pathways, including cancer progression, whilst their expression in various tumor types may be associated with patient prognosis. However, the role of the RBP family members has not been explored in colon cancer and their possible use as prognostic biomarkers is largely unknown. MATERIALS AND METHODS: RESULTS: We examined the RNA expression of IGFBP2, RBM3, and CIRP in 94 human colon cancer samples along with matched normal tissue samples from each patient using quantitative real-time polymerase chain reaction (qRT-PCR). No significant associations were observed between RNA expression of RBPs and the studied clinical features. The estimated 5-year disease-free survival rate was significantly better for patients with higher expression of RBM3 and CIRP, while patient survival was not significantly correlated to IGFBP2 expression. CONCLUSION:
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Authors | Ho Hee Jang, Hae Na Lee, So-Young Kim, Suntaek Hong, Won-Suk Lee |
Journal | Anticancer research
(Anticancer Res)
Vol. 37
Issue 4
Pg. 1779-1785
(04 2017)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 28373441
(Publication Type: Journal Article)
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Copyright | Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- CIRBP protein, human
- Eye Proteins
- RNA, Messenger
- RNA-Binding Proteins
- Retinol-Binding Proteins
- interstitial retinol-binding protein
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Topics |
- Adenocarcinoma
(genetics, pathology)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(genetics)
- Colonic Neoplasms
(genetics, pathology)
- Eye Proteins
(genetics)
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Staging
- Prognosis
- RNA, Messenger
(genetics)
- RNA-Binding Proteins
(genetics)
- Real-Time Polymerase Chain Reaction
- Retinol-Binding Proteins
(genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Survival Rate
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