Abstract |
A series of copper(II) complexes with tripodal polypyridylamine ligands (derived from the parent ligand tris(2-pyridylmethyl) amine, tmpa) has been synthesized. Crystallographic characterization was possible for all complexes obtained. The copper(II) chloride complexes were investigated for their in vitro anticancer potential using human tumor cell lines containing examples of cervical, colon, ovarian cancers and melanoma. Some compounds showed a similar activity compared to that of cisplatin, however no systematic behavior could be observed.
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Authors | Melanie Jopp, Jonathan Becker, Sabine Becker, Andreas Miska, Valentina Gandin, Cristina Marzano, Siegfried Schindler |
Journal | European journal of medicinal chemistry
(Eur J Med Chem)
Vol. 132
Pg. 274-281
(May 26 2017)
ISSN: 1768-3254 [Electronic] France |
PMID | 28371639
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Ligands
- Organometallic Compounds
- Pyridines
- tris(2-pyridylmethyl)amine
- Copper
- Cisplatin
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Cell Line, Tumor
- Cisplatin
(pharmacology)
- Copper
(chemistry)
- Crystallography, X-Ray
- Humans
- Ligands
- Organometallic Compounds
(chemistry, pharmacology)
- Pyridines
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