Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: Chinese gestational diabetes patients who underwent a 100-g oral glucose tolerance test in Peking Union Medical College Hospital from July 2005 to May 2008 were retrospectively analyzed. Participants were selected for direct sequencing of the GCK gene if they met the following criteria: (i) fasting plasma glucose between 5.5 and 10.0 mmol/L; and (ii) a small increment (<4.6 mmol/L) during a 2-h oral glucose tolerance test. RESULTS: Of the 501 participants with gestational diabetes, there were 38 participants who met the criteria for GCK analysis. In the 29 participants whose deoxyribonucleic acid samples were available, two mutations in coding regions were detected, c.626 C>T (p.T209M, NP_000153.1) mutation in exon 6 and c.824 G>A (p.R275H, NP_000153.1; rs767565869) mutation in exon 7. According to our results, the minimum prevalence of GCK mutations in Chinese women with gestational diabetes was estimated to be 0.4%, and the minimum prevalence of GCK maturity-onset diabetes of the young in the Chinese population might be one in 2,000. CONCLUSIONS:
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Authors | Zhixin Wang, Fan Ping, Qian Zhang, Jia Zheng, Huabing Zhang, Miao Yu, Wenhui Li, Xinhua Xiao |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 9
Issue 1
Pg. 199-203
(Jan 2018)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 28371533
(Publication Type: Journal Article)
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Copyright | © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
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Topics |
- Asian People
(genetics)
- China
- Diabetes, Gestational
(enzymology, genetics)
- Female
- Genetic Predisposition to Disease
- Glucokinase
(genetics)
- Humans
- Mutation
- Pregnancy
- Retrospective Studies
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