Abstract | BACKGROUND: AIMS: This study is an observational, record-based study comparing the effectiveness and safety of patients receiving cyclosporine versus only supportive therapy. METHODOLOGY: Medical records as bed-head tickets and laboratory investigation reports of Stevens-Johnson syndrome/toxic epidermal necrolysis patients admitted in the hospital over a period of 1 year were collected. Data regarding clinico-demographic profile, suspected drug causing Stevens-Johnson's syndrome/ toxic epidermal necrolysis, SCORTEN, body surface area involved, treatment received and outcome were obtained. RESULTS: Twenty-eight patients were analyzed. Nineteen belonged to the cyclosporine group (supportive treatment + cyclosporine), nine to supportive treatment only group. Among the suspected drugs, antiepileptics formed the major group (28.6%). Five patients in the supportive only group and one in the cyclosporine group died. Time for stabilization and reepithelialization and duration of recovery were significantly lower in the cyclosporine group (P < 0.001, P= 0.007, P= 0.01, respectively). The standardized mortality ratio was 0.32 in cyclosporine group which is nearly 3.3 times lower than the only supportive treatment. LIMITATIONS: As it was a record-based study, certain confounding factors (serum blood urea nitrogen) could not be adjusted. CONCLUSION:
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Authors | Swosti Mohanty, Anupam Das, Anupama Ghosh, Amrita Sil, Ramesh Chandra Gharami, Debabrata Bandyopadhyay, Nilay Kanti Das |
Journal | Indian journal of dermatology, venereology and leprology
(Indian J Dermatol Venereol Leprol)
2017 May-Jun
Vol. 83
Issue 3
Pg. 312-316
ISSN: 0973-3922 [Electronic] United States |
PMID | 28366923
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Chemical References |
- Dermatologic Agents
- Cyclosporine
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Topics |
- Adult
- Cyclosporine
(adverse effects, therapeutic use)
- Dermatologic Agents
(adverse effects, therapeutic use)
- Female
- Headache
(chemically induced)
- Humans
- Male
- Medical Records
- Middle Aged
- Nausea
(chemically induced)
- Stevens-Johnson Syndrome
(diagnosis, drug therapy)
- Treatment Outcome
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