Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

Abstract

BACKGROUND:

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited.

METHODS:

Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths).

RESULTS:

Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)).

CONCLUSIONS:

Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

• Authors: Suzanne C Dixon, Christina M Nagle, Nicolas Wentzensen, Britton Trabert, Alicia Beeghly-Fadiel, Joellen M Schildkraut, Kirsten B Moysich, Anna deFazio, Australian Ovarian Cancer Study Group, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Allan Jensen, Susanne K Kjær, Estrid Høgdall, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elizabeth M Poole, Elisa V Bandera, Lisa E Paddock, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Malcolm C Pike, Penelope M Webb
• Journal: British journal of cancer (Br J Cancer) Vol. 116 Issue 9 Pg. 1223-1228 (Apr 25 2017) ISSN: 1532-1827 [Electronic] England
• PMID: 28350790 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Anticarcinogenic Agents
• Acetaminophen
• Aspirin

Topics

• Acetaminophen (therapeutic use)
• Adult
• Aged
• Analgesics (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Anticarcinogenic Agents (therapeutic use)
• Aspirin (therapeutic use)
• Disease-Free Survival
• Female
• Humans
• Middle Aged
• Ovarian Neoplasms (drug therapy, epidemiology, pathology)
• Proportional Hazards Models
• Risk Factors