Abstract |
Glomus jugulare tumors have the ability to synthesize, store, and secrete biogenic amines. Although the majority of these tumors remain endocrinologically silent, on rare occasions they present either as a pheochromocytoma or with a carcinoid syndrome. We report a 20-year-old male with two intracranial tumors: an intrasellar neoplasm and a glomus jugulare tumor. Catecholamine catabolites in the urine were not increased, and blood pressure was always normal. The pituitary tumor was an adenoma, immunostaining positive for prolactin. The second patient, a 29-year-old hypertensive male, with a glomus jugulare tumor, had increased vanillylmandelic-acid excretion. In both cases, the paraganglioma tumor cells contained numerous dense-core vesicles (125 to 380 nm in diameter) in electron microscopy, and showed intense fluorescence by the sucrose- potassium phosphate- glyoxylic acid method. Using high-performance liquid chromatography and microspectrofluorometry we were able to establish the presence of large amounts of dopamine in the cytoplasm of the tumor cells.
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Authors | B Azzarelli, S Felten, J Muller, R Miyamoto, V Purvin |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 98
Issue 5
Pg. 573-8
(May 1988)
ISSN: 0023-852X [Print] United States |
PMID | 2834616
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adenoma
(pathology)
- Adult
- Child, Preschool
- Chromatography, High Pressure Liquid
- Cytoplasm
(analysis)
- Dopamine
(analysis)
- Glomus Jugulare Tumor
(analysis, metabolism, pathology, ultrastructure)
- Histocytochemistry
- Humans
- Male
- Microscopy, Electron
- Neoplasms, Multiple Primary
- Paraganglioma, Extra-Adrenal
(analysis)
- Pituitary Neoplasms
(pathology)
- Spectrometry, Fluorescence
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