Abstract | BACKGROUND: Several studies have suggested sex-related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aimed to compare sex-related differences in in-hospital outcomes of patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease, non-ST elevation acute coronary syndromes, ST elevation myocardial infarction, and cardiogenic shock. From 2007 until the end of 2009 data from 185 312 PCIs were prospectively registered: 27.9% of the PCIs were performed in women. Primary PCI success rate was identical between the sexes (94%). There were no sex-related differences in hospital mortality among patients undergoing PCI for stable coronary artery disease, non-ST elevation acute coronary syndromes, or cardiogenic shock except among ST elevation myocardial infarction patients. Compared to men, women undergoing primary PCI for ST elevation myocardial infarction have a higher risk of in-hospital death, age-adjusted odds ratio (1.19, 95% CI 1.06-1.33), and risk of ischemic cardiac and cerebrovascular events (death, myocardial infarction, transient ischemic attack/ stroke), (age-adjusted odds ratio 1.19, 95% CI 1.16-1.29). Furthermore, access-related complications were twice as high in women, irrespective of the indication. CONCLUSIONS: Despite identical technical success rates of PCI between the 2 sexes, women with PCI for ST elevation myocardial infarction have a 20% higher age-adjusted risk of death and of ischemic cardiac and cerebrovascular events. Further research is needed to determine the reasons for these differences.
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Authors | Tobias Heer, Matthias Hochadel, Karin Schmidt, Julinda Mehilli, Ralf Zahn, Karl-Heinz Kuck, Christian Hamm, Michael Böhm, Georg Ertl, Hans Martin Hoffmeister, Stefan Sack, Jochen Senges, Steffen Massberg, Anselm K Gitt, Uwe Zeymer |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 6
Issue 3
(Mar 20 2017)
ISSN: 2047-9980 [Electronic] England |
PMID | 28320749
(Publication Type: Journal Article)
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Copyright | © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. |
Topics |
- Acute Coronary Syndrome
(surgery)
- Age Factors
- Aged
- Cardiology
- Coronary Angiography
- Coronary Artery Disease
(surgery)
- Female
- Germany
- Hospital Mortality
- Humans
- Male
- Middle Aged
- Non-ST Elevated Myocardial Infarction
(surgery)
- Odds Ratio
- Percutaneous Coronary Intervention
(methods)
- Registries
- ST Elevation Myocardial Infarction
(surgery)
- Sex Factors
- Shock, Cardiogenic
(surgery)
- Societies, Medical
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