Abstract | OBJECTIVE: MATERIALS AND METHODS: Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers. RESULTS: Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001). CONCLUSION: Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism.
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Authors | Ahmet Menteşe, Nergiz Erkut, Selim Demir, Serap Özer Yaman, Ayşegül Sümer, Şeniz Doğramacı, Ahmet Alver, Mehmet Sönmez |
Journal | Turkish journal of haematology : official journal of Turkish Society of Haematology
(Turk J Haematol)
Vol. 34
Issue 4
Pg. 307-313
(12 01 2017)
ISSN: 1308-5263 [Electronic] Turkey |
Vernacular Title | Akut Miyeloid Lösemi Hastalarında Karbonik Anhidraz I ve II Otoantikorları. |
PMID | 28270370
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Carbonic Anhydrase I
- Carbonic Anhydrase II
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Topics |
- Adult
- Aged
- Autoantibodies
(blood, immunology)
- Carbonic Anhydrase I
(immunology)
- Carbonic Anhydrase II
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Leukemia, Myeloid, Acute
(blood, immunology)
- Male
- Middle Aged
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