Abstract | BACKGROUND & AIMS: METHODS:
Critically ill cirrhotics were included over a time period of 6 years and followed for at least 1 year. CLIF-C ACLF, CLIF-SOFA, SOFA and MELD scores on admission, 24 h prior to RRT, 24 and 48 hours after start of RRT were analysed for their predictive value of ICU-mortality. Additionally, long-term renal recovery and successful bridging to LT was assessed. RESULTS: In total, 40% (78/193) of patients required RRT. ICU-, 28 days-, 90 days-, and 1 year-mortality was 71%, 83%, 91%, and 92%, respectively, and was significantly higher than in patients without need for RRT (4%, 30%, 43%, and 50%), P<.001. CLIF-C ACLF and CLIF - SOFA scores within 24 hours prior to RRT showed good discriminant power to predict ICU-mortality. CLIF-C ACLF calculated 48 hours after commencing RRT was the most suitable predictor of ICU-mortality in RRT-patients irrespective of LT options (AUC: 0.866). In patients with ≥5 organ failure assessed by CLIF-SOFA at any time point showed 100% ICU-mortality. 13% of patients with RRT showed renal recovery; 14% of patients could be bridged to LT. CONCLUSIONS: Mortality in critically ill cirrhotics with need for RRT is substantially high independent of LT options. Only a small proportion showed renal recovery after ICU discharge. CLIF-C ACLF and CLIF-SOFA score may assist in identifying patients who would not benefit from RRT.
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Authors | Katharina Staufer, Kevin Roedl, Danijel Kivaranovic, Andreas Drolz, Thomas Horvatits, Susanne Rasoul-Rockenschaub, Christian Zauner, Michael Trauner, Valentin Fuhrmann |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 37
Issue 6
Pg. 843-850
(06 2017)
ISSN: 1478-3231 [Electronic] United States |
PMID | 28211257
(Publication Type: Journal Article)
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Copyright | © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Topics |
- Acute-On-Chronic Liver Failure
(mortality)
- Adult
- Aged
- Austria
(epidemiology)
- Critical Illness
(mortality)
- Female
- Humans
- Intensive Care Units
- Liver
(physiopathology)
- Liver Cirrhosis
(complications, mortality, therapy)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Organ Dysfunction Scores
- Prognosis
- ROC Curve
- Renal Replacement Therapy
(statistics & numerical data)
- Retrospective Studies
- Tertiary Care Centers
- Time Factors
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