Abstract |
Pharmacotherapy of multidrug resistant (MDR) cancer remains a challenging task in clinic. Herein, a pH-responsive DNA and disulfide-linked polyethylenimine functionalized gold nanorod was developed for specific co-delivery of chemotherapeutic agent doxorubicin (DOX) and chemosensitizer pyronaridine (PND) to effectively overcome MDR cancer cells. DOX and PND were firstly carried by a multifunctional nanocomplex for reversing MDR cancer. The nanocomplex can responsively and rapidly release its drugs payload under acidic pH environment (pH, ~5), intracellular GSH concentration content (5 mM) and/or 808 nm NIR laser irradiation. Compared to free DOX, the nanocomplex displayed greatly increased cytotoxicity to MDR MCF-7/ADR cancer cells (IC50, 70.68:6.21 μg/mL). The application of NIR radiation further improved the DOX release and enhanced the antitumor effects of the namomedicine (IC50, drops to 2.88 μg/mL). Consequently, this new nanocomplex exerted greatly increased potency against the MDR cancer cells over free DOX (~20 fold).
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Authors | Yun Wang, Zhipeng Zhang, Shaohui Xu, Feihu Wang, Yuanyuan Shen, Shengtang Huang, Shengrong Guo |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 13
Issue 5
Pg. 1785-1795
(07 2017)
ISSN: 1549-9642 [Electronic] United States |
PMID | 28185939
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibiotics, Antineoplastic
- Drug Carriers
- Gold
- Doxorubicin
- Polyethyleneimine
- DNA
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Topics |
- Antibiotics, Antineoplastic
(administration & dosage, pharmacology)
- DNA
- Doxorubicin
(administration & dosage, pharmacology)
- Drug Carriers
- Gold
- Humans
- Hydrogen-Ion Concentration
- Nanotubes
- Oxidation-Reduction
- Polyethyleneimine
- Tumor Cells, Cultured
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