Independent Association between Hyperuricemia and Histopathological Parameters in Chinese Patients with Henöch-Schönlein Purpura Nephritis.

Abstract

BACKGROUND:

This study aimed to investigate the role of hyperuricemia in the development of histopathological changes in HSPN.

METHODS:

Clinical and laboratory data pertaining to 139 adult HSPN patients with and without elevated serum uric acid levels were retrospectively evaluated. There was a 14.4% prevalence of hyperuricemia in patients with HSPN.

RESULTS:

Patients with hyperuricemia had higher levels of cystatin C and urine β2-microglobulin and lower levels of HDL-C in comparison to that in patients with normal serum uric acid levels (p < 0.05). Patients with hyperuricemia had higher scores of interstitial inflammation, tubular atrophy, interstitial fibrosis, glomerulosclerosis as compared to those normouricemic patients (p < 0.05). Serum uric acid was found to be correlated independently with the presence of interstitial inflammation, tubular atrophy, interstitial fibrosis, and glomerulosclerosis by multivariate analysis (p < 0.05).

CONCLUSIONS:

High serum uric acid may be independently correlated with the development of tubulointerstitial lesions as well as glomerulosclerosis in HSPN.

• Authors: Shan Lu, Dong Liu, Jing Xiao, Genyang Cheng, Xiaoyang Wang, Xiaoxue Zhang, Wenming Yuan, Yanna Dou, Zhangsuo Liu, Zhanzheng Zhao
• Journal: Clinical laboratory (Clin Lab) Vol. 62 Issue 11 Pg. 2271-2275 (Nov 01 2016) ISSN: 1433-6510 [Print] Germany
• PMID: 28164660 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• CST3 protein, human
• Cholesterol, HDL
• Cystatin C
• beta 2-Microglobulin
• Uric Acid

Topics

• Adult
• Biomarkers (blood, urine)
• China (epidemiology)
• Cholesterol, HDL (blood)
• Cystatin C (blood)
• Female
• Glomerulonephritis (blood, diagnosis, epidemiology)
• Humans
• Hyperuricemia (blood, diagnosis, epidemiology)
• IgA Vasculitis (blood, diagnosis, epidemiology)
• Kidney (pathology)
• Male
• Middle Aged
• Prevalence
• Retrospective Studies
• Risk Factors
• Uric Acid (blood)
• Young Adult
• beta 2-Microglobulin (urine)