Photothermal therapeutic application of gold nanorods-porphyrin-trastuzumab complexes in HER2-positive breast cancer.

Abstract

Gold nanorods are effective photothermal agents in diagnosis and treatment of cancer due to their specific near-infrared laser absorption. However, tumor photothermal therapy by nanorods alone is lack of targeting. Here, we described a novel nanocomplex made up of gold nanorods, porphyrin, and trastuzumab, called TGNs and investigated the TGN-mediated photothermal therapy as a potential alternative treatment of targeting HER2-positive breast cancers. By conjugating trastuzumab and porphyrin to the surface of gold nanorods, we have increased the targeting specificity and amplified the detecting effectiveness at the same time. TGN-mediated photothermal ablation by near-infrared laser led to a selective destruction of HER2-positive cancer cells and significantly inhibited tumor growth in mouse models bearing HER2 over-expressed breast cancer xenograft with less toxicity. Moreover, TGNs provided better therapeutic efficacy in comparison with the conventional molecule targeted therapy. Our current data suggest a highly promising future of TGNs for its therapeutic application in trastuzumab-resistant breast cancers.

• Authors: Xinmei Kang, Ximing Guo, Xingjian Niu, Weiwei An, Suhan Li, Zhaoliang Liu, Yue Yang, Na Wang, Qicheng Jiang, Caichuan Yan, Hui Wang, Qingyuan Zhang
• Journal: Scientific reports (Sci Rep) Vol. 7 Pg. 42069 (02 03 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 28155894 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Immunological
• Drug Carriers
• Porphyrins
• Gold
• Trastuzumab

Topics

• Animals
• Antineoplastic Agents, Immunological (administration & dosage)
• Breast Neoplasms (therapy)
• Disease Models, Animal
• Drug Carriers (administration & dosage)
• Gold (administration & dosage)
• Heterografts
• Humans
• Hyperthermia, Induced (methods)
• Mice
• Molecular Targeted Therapy (methods)
• Nanotubes
• Neoplasm Transplantation
• Phototherapy (methods)
• Porphyrins (administration & dosage)
• Trastuzumab (administration & dosage)
• Treatment Outcome