Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.

Abstract

Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues. In addition, IGFBP-4 could inhibit lung cancer cell proliferation, migration and invasion, and suppress the phosphorylation of PI3 K/AKT, ERK, and CREB. These results indicate that IGFBP-4 has potent antitumor effects in non-small cell lung cancer cells.

• Authors: Weiwen Li, Debin Sun, Zhuqing Lv, Yueqiu Wei, Liyun Zheng, Tingting Zeng, Jialu Zhao
• Journal: Cell biology international (Cell Biol Int) Vol. 41 Issue 4 Pg. 384-391 (Apr 2017) ISSN: 1095-8355 [Electronic] England
• PMID: 28150906 (Publication Type: Journal Article)
• Copyright: © 2017 International Federation for Cell Biology.

Chemical References

• Antineoplastic Agents
• Insulin-Like Growth Factor Binding Protein 4
• Lipopolysaccharides
• Cyclooxygenase 2
• PTGS2 protein, human
• Phosphatidylinositol 3-Kinases

Topics

• A549 Cells
• Antineoplastic Agents (pharmacology)
• Cell Movement
• Cell Proliferation
• Cyclooxygenase 2 (metabolism)
• Down-Regulation
• Drug Screening Assays, Antitumor
• Humans
• Insulin-Like Growth Factor Binding Protein 4 (pharmacology, physiology)
• Lipopolysaccharides (pharmacology)
• Lung Neoplasms (drug therapy, immunology, metabolism, pathology)
• Neoplasm Invasiveness
• Phosphatidylinositol 3-Kinases (metabolism)
• Phosphorylation
• Protein Processing, Post-Translational
• Signal Transduction