HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Insulin-Like Growth Factor Binding Protein 4

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
Also Known As:
IGF Binding Protein 4; Insulin Like Growth Factor Binding Protein 4; IGF-Binding Protein 4; IGFBP-4
Networked: 167 relevant articles (3 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hjortebjerg, Rikke: 7 articles (11/2020 - 03/2015)
2. Frystyk, Jan: 6 articles (11/2020 - 03/2015)
3. Oxvig, Claus: 6 articles (01/2018 - 01/2013)
4. Conover, Cheryl A: 4 articles (10/2015 - 12/2006)
5. Baylink, D J: 4 articles (02/2001 - 02/2000)
6. Mohan, S: 4 articles (02/2001 - 02/2000)
7. Katrukha, Alexey G: 3 articles (11/2021 - 05/2018)
8. Konev, Alexey A: 3 articles (11/2021 - 05/2018)
9. Postnikov, Alexander B: 3 articles (11/2021 - 05/2018)
10. Serebryanaya, Daria V: 3 articles (11/2021 - 05/2018)

Related Diseases

1. Neoplasms (Cancer)
2. Hyperglycemia
3. Neoplasm Metastasis (Metastasis)
11/15/2011 - "This is a first report documenting that IGFBP-4 expression in RCC activates cell growth, metastasis, Wnt/beta-catenin signaling and may be involved in RCC metastasis."
10/22/2018 - "Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer."
02/01/2014 - "The HCC-BDTT demonstrated increased expression in IL-6 and stemness factor Bmi1, but reduced level of metastasis-suppressive protein, insulin-like growth factor-binding protein 4. The invasive ability of the highly aggressive Mahlavu cell was attenuated by pre-miR-200c+141, whereas the invasive ability of the less aggressive Huh7 cell was enhanced by anti-miR-200c+141. "
04/10/2004 - "Here, we show that regulation of uPA mRNA and protein by IGF-I depends on the PI3K and MAPK signaling pathways and phosphorylation of Akt and ERK1/2 is required for IGF-I-mediated cell invasion; that IGFBP-4 protease in HRA cells is identified as PAPP-A; that reduced PAPP-A expression is associated with the upregulation of IGFBP-4 expression; that higher intact IGFBP-4 levels were associated with low invasive potential and growth rate in AS-PAPP-A cells in response to IGF-I; that IGF-I stimulates Akt and ERK1/2 activation of both the control and antisense cells, but the relative potency and efficacy of IGF-I were lower in the antisense cells compared to the control; and that genetic downregulation of PAPP-A reduces the proliferation, invasion and metastasis of HRA cells. "
01/01/2019 - "The effects of miR-141 mimics were investigated with respect to angiogenesis by vascular endothelial growth factor (VEGF), epithelial-mesenchymal transition (EMT) by E-cadherin, metastasis by Igfbp-4 and Tinagl1 enzyme-linked immunosorbent assays, invasion by an invasion chamber, and apoptosis by Annexin V. The miR-141 expression levels of MDA-MB-231 and MDA-MB-435 cells by administration of chitosan/mimic miR-141 nanoplexes reached endogenous miR-141 levels of a non-tumorigenic epithelial breast cell line, MCF-10A. "
4. Colonic Neoplasms (Colon Cancer)
5. Osteosarcoma (Osteogenic Sarcoma)

Related Drugs and Biologics

1. Insulin-Like Growth Factor I (IGF-1)
2. Pregnancy-Associated Plasma Protein-A (PAPP-A)
3. Insulin-Like Growth Factor Binding Protein 3
4. Messenger RNA (mRNA)
5. Anthocyanins (Anthocyanin)
6. Proteins (Proteins, Gene)
7. Glucose (Dextrose)
8. C-Peptide
9. Insulin-Like Growth Factor II (Somatomedin A)
10. Insulin-Like Growth Factor Binding Protein 2

Related Therapies and Procedures

1. Glycemic Control
2. Aftercare (After-Treatment)
3. Therapeutics
4. Length of Stay
5. Ligation