Abstract | BACKGROUND: METHODS: We reviewed the published papers on the relation between circulating PCSK9 and diabetogenesis. RESULTS: Recent data suggest that increased circulating PCSK9 levels, besides causing dyslipidaemia, are related to increased glucose levels, metabolic syndrome, and even T2DM. On the contrary, fasting plasma glucose and HbA1c levels are not adversely affected during treatment with human antibodies against PCSK9 in patients at low risk for T2DM, in patients at high risk of T2DM and in patients with established T2DM. Plasma lipoproteins (mainly LDL-C reduction) are similarly affected in patients with or without T2DM, and recent data suggest that PCSK9 inhibition might reduce cardiovascular events in patients with T2DM at least as much as in those without T2DM. CONCLUSION: The use of PCSK9 inhibitors appears to be related to a substantial clinical benefit without adversely affecting glucose metabolism and without increasing the incidence of NODM. Large ongoing studies will have to confirm these findings before expanding the use of these agents.
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Authors | Vasilios G Athyros, Konstantinos Tziomalos, Michael Doumas, George Sfikas, Asterios Karagiannis |
Journal | Current pharmaceutical design
(Curr Pharm Des)
Vol. 23
Issue 10
Pg. 1477-1483
( 2017)
ISSN: 1873-4286 [Electronic] United Arab Emirates |
PMID | 28128061
(Publication Type: Journal Article, Meta-Analysis, Review)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Antibodies, Monoclonal
- Anticholesteremic Agents
- Cholesterol, LDL
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hypolipidemic Agents
- PCSK9 Inhibitors
- Serine Proteinase Inhibitors
- PCSK9 protein, human
- Proprotein Convertase 9
- Glucose
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Topics |
- Antibodies, Monoclonal
(chemistry, pharmacology)
- Anticholesteremic Agents
(chemistry, pharmacology)
- Cardiovascular Diseases
(drug therapy, metabolism)
- Cholesterol, LDL
(antagonists & inhibitors, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Glucose
(antagonists & inhibitors, metabolism)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(chemistry, pharmacology)
- Hypolipidemic Agents
(chemistry, pharmacology)
- PCSK9 Inhibitors
- Proprotein Convertase 9
(blood, metabolism)
- Serine Proteinase Inhibitors
(chemistry, pharmacology)
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