Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions.

Abstract

AIM:

The purpose of this study was to determine whether C-reactive protein (CRP) in the first 1-3 days post-transplant could predict allogeneic immune reactions, including engraftment syndrome or acute graft-versus-host disease (GVHD), in pediatric haploidentical stem cell transplantation.

PATIENTS & METHODS:

The study population comprised 175 consecutive pediatric patients. Receiver operating characteristic analysis was performed to identify the cut-off CRP value.

RESULTS:

The high-CRP group (≥20.1 mg/l) was associated with an increased occurrence of engraftment syndrome (hazard ratio [HR] = 2.046; p = 0.008), II-IV acute GVHD (HR = 2.203; p = 0.001) and severe GVHD (HR = 6.371; p = 0.004).

CONCLUSION:

Our data suggest that higher CRP during the first 1-3 days post-transplant could be a predictor of allogeneic immune reactions.

• Authors: Yao Chen, Xiao-Jun Huang, Kai-Yan Liu, Huan Chen, Yu-Hong Chen, Xiao-Hui Zhang, Yu Wang, Feng-Rong Wang, Wei Han, Jing-Zhi Wang, Chen-Hua Yan, Lan-Ping Xu
• Journal: Biomarkers in medicine (Biomark Med) Vol. 11 Issue 2 Pg. 117-124 (Feb 2017) ISSN: 1752-0371 [Electronic] England
• PMID: 28111964 (Publication Type: Journal Article)

Chemical References

• C-Reactive Protein

Topics

• Adolescent
• Area Under Curve
• C-Reactive Protein (analysis)
• Child
• Child, Preschool
• Female
• Graft vs Host Disease (diagnosis, etiology, mortality)
• Haplotypes
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Immunity, Innate
• Male
• Proportional Hazards Models
• ROC Curve
• Risk Factors
• Severity of Illness Index
• Survival Rate
• Time Factors
• Transplantation, Homologous