Neoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery and neoangiogenesis, through that further confer cell survival improvement. Plants still acts as reservoir of natural chemicals to provide newer active pharmacophores.
Scutellarein is
flavones which has wide range of pharmacophoral effects. In our current research,
scutellarein employed for targeting oxidative stress mediated
tumor angiogenesis and apoptotic nuclear fragmentation. Experimental results revealed that
scutellarein has antiproliferative index against multiple
cancer cell lines and diminished the oxidative stress and
tumor development of murine ascitic
lymphoma & inflammatory
hepatocellular carcinoma. Eventual consequences lead to reduced neovessel formation by abrogating angiogeneic factors
cytokine-
VEGF-A, Flt-1, HIF-1α, MMP-2 and MMP-9 and reversing of evading apoptosis by activating
caspase-3 activated DNA fragmentation factor (DFF-40) mediated nucleosomal degradation. In summary, our experimental evidences suggest that
scutellarein has strong potentiality to attenuate the
tumor development by modulating sprouting neovasculature and DFF-40 mediated apoptosis.