Decreased intestinal acetylcholinesterase in early Parkinson disease: An 11C-donepezil PET study.

Abstract

OBJECTIVE:

To investigate systemic levels of acetylcholinesterase in early Parkinson disease (PD) with 11C-donepezil PET, a potential marker of parasympathetic innervation.

METHODS:

This was a cross-sectional study with 19 patients with early-stage PD (disease duration 1.5 ± 0.6 years) and 16 age-matched controls who had clinical assessments, olfaction tests, and 11C-donepezil PET to measure acetylcholinesterase density in peripheral organs.

RESULTS:

The patients with PD showed significantly reduced 11C-donepezil uptake in the small intestine (-14%, p = 0.018), colon (-22%, p < 0.001), and kidneys (-14%, p = 0.028). No difference in myocardial or pancreatic acetylcholinesterase levels was seen.

CONCLUSION:

We found significantly decreased 11C-donepezil signal in the intestine and kidneys of patients with early PD, suggesting that parasympathetic denervation is present early in the disease course.

• Authors: Tatyana D Fedorova, Louise B Seidelin, Karoline Knudsen, Anna C Schacht, Jacob Geday, Nicola Pavese, David J Brooks, Per Borghammer
• Journal: Neurology (Neurology) Vol. 88 Issue 8 Pg. 775-781 (Feb 21 2017) ISSN: 1526-632X [Electronic] United States
• PMID: 28100726 (Publication Type: Journal Article)
• Copyright: © 2017 American Academy of Neurology.

Chemical References

• Carbon Radioisotopes
• Indans
• Piperidines
• Radiopharmaceuticals
• Donepezil
• Acetylcholinesterase

Topics

• Acetylcholinesterase (metabolism)
• Aged
• Area Under Curve
• Carbon Radioisotopes
• Cross-Sectional Studies
• Donepezil
• Female
• Heart (diagnostic imaging)
• Humans
• Indans
• Intestines (diagnostic imaging, enzymology)
• Kidney (diagnostic imaging, enzymology)
• Male
• Middle Aged
• Myocardium (enzymology)
• Pancreas (diagnostic imaging, enzymology)
• Parkinson Disease (diagnostic imaging, enzymology)
• Piperidines
• Positron-Emission Tomography
• ROC Curve
• Radiopharmaceuticals
• Time Factors