A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

Abstract

West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

• Authors: Kristen K Pierce, Stephen S Whitehead, Beth D Kirkpatrick, Palmtama L Grier, Adrienne Jarvis, Heather Kenney, Marya P Carmolli, Cynthia Reynolds, Cecilia M Tibery, Janece Lovchik, Anna Janiak, Catherine J Luke, Anna P Durbin, Alexander G Pletnev
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 215 Issue 1 Pg. 52-55 (Jan 01 2017) ISSN: 1537-6613 [Electronic] United States
• PMID: 28077583 (Publication Type: Journal Article)
• Copyright: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected].

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Vaccines, Attenuated
• West Nile Virus Vaccines

Topics

• Adult
• Age Factors
• Aged
• Antibodies, Neutralizing (blood)
• Antibodies, Viral (blood)
• Disease Outbreaks
• Female
• Humans
• Male
• Middle Aged
• Seroconversion
• United States
• Vaccines, Attenuated (administration & dosage, adverse effects, immunology)
• Viremia
• West Nile Fever (epidemiology)
• West Nile Virus Vaccines (administration & dosage, adverse effects, genetics, immunology)
• West Nile virus (immunology)