Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study.

Abstract

INTRODUCTION:

The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort.

METHODS:

We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004-2006 and 2011-2013.

RESULTS:

After a mean follow-up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow-up visit.

CONCLUSION:

A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.

• Authors: Danni Li, Jeffrey R Misialek, Eric Boerwinkle, Rebecca F Gottesman, A Richey Sharrett, Thomas H Mosley, Josef Coresh, Lisa M Wruck, David S Knopman, Alvaro Alonso
• Journal: Alzheimer's & dementia (Amsterdam, Netherlands) (Alzheimers Dement (Amst)) Vol. 6 Pg. 1-10 ( 2017) ISSN: 2352-8729 [Print] United States
• PMID: 28054030 (Publication Type: Journal Article)