Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke.

Abstract

There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which vitamin D deficiency leads from endothelial dysfunction to myocardial infarction and stroke are not fully understood. Thus, the goal of this review is to provide an updated review of the literature on the basic science of how vitamin D may affect the cardiovascular system and in particular to analyze the role that vitamin D may have in the whole dynamic process from the initiation of endothelial dysfunction to the development of myocardial infarction and stroke.

• Authors: Giovanna Muscogiuri, Cedric Annweiler, Guillaume Duval, Spyridon Karras, Giacomo Tirabassi, Gianmaria Salvio, Giancarlo Balercia, Samantha Kimball, Kalliopi Kotsa, Luca Mascitelli, Harjit Pal Bhattoa, Annamaria Colao
• Journal: International journal of cardiology (Int J Cardiol) Vol. 230 Pg. 577-584 (Mar 01 2017) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 28043680 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016. Published by Elsevier B.V.

Chemical References

• Vitamins
• Vitamin D

Topics

• Atherosclerosis (complications, drug therapy)
• Humans
• Myocardial Infarction (etiology, prevention & control)
• Stroke (etiology, prevention & control)
• Vitamin D (therapeutic use)
• Vitamin D Deficiency (complications, drug therapy)
• Vitamins (therapeutic use)