Purified Lesser weever fish venom (Trachinus vipera) induces eryptosis, apoptosis and cell cycle arrest.

Abstract

Accidents caused by the sting of Trachinus vipera (known as Lesser weever fish) are relatively common in shallow waters of the Mediterranean. Symptoms after the sting vary from severe pain to edema or even tissue necrosis in some cases. Here we show that purified Lesser weever fish venom induces eryptosis, the suicidal erythrocyte death, and apoptosis of human colon carcinoma cells. The venom leads to erythrocyte shrinkage, phosphatidylserine translocation and increased intracellular Ca2+, events typical for eryptosis. According to mitochondrial staining cancer cells dyed after the activation of the intrinsic apoptotic pathway. Trachinus vipera venom further causes cell cycle arrest.

• Authors: Myriam Fezai, Chaker Slaymi, Mossadok Ben-Attia, Florian Lang, Mohamed Jemaà
• Journal: Scientific reports (Sci Rep) Vol. 6 Pg. 39288 (12 20 2016) ISSN: 2045-2322 [Electronic] England
• PMID: 27995979 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fish Venoms
• Phosphatidylserines
• Calcium

Topics

• Animals
• Apoptosis (drug effects)
• Bites and Stings
• Calcium (metabolism)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Colonic Neoplasms (drug therapy)
• Eryptosis (drug effects)
• Erythrocytes (pathology)
• Fish Venoms (pharmacology)
• HCT116 Cells
• Humans
• Perciformes (metabolism)
• Phosphatidylserines (metabolism)
• Tunisia