Olmesartan-induced Enteropathy Manifesting as Wernicke-Korsakoff Syndrome.

Abstract

Cases of sprue-like enteropathy associated with olmesartan have sporadically been encountered since it was first reported in 2012, and their most characteristic manifestation is severe diarrhea. We herein report the first case of sprue-like enteropathy manifesting as Wernicke-Korsakoff syndrome due to vitamin B1 malabsorption with only minimally increased bowel movements. When patients are receiving olmesartan and they complain of nonspecific chronic gastrointestinal symptoms, it is important to consider changing the drugs before any serious malabsorption syndrome develops.

• Authors: Takanori Uehara, Masatomi Ikusaka, Yoshiyuki Ohira, Kazutaka Noda, Shingo Suzuki, Kiyoshi Shikino, Takeshi Kondo, Hideki Kajiwara, Akiko Ikegami, Yusuke Hirota
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) 2016 Vol. 55 Issue 24 Pg. 3675-3678 ISSN: 1349-7235 [Electronic] Japan
• PMID: 27980272 (Publication Type: Case Reports, Journal Article)

Chemical References

• Imidazoles
• Tetrazoles
• Vitamin B Complex
• olmesartan
• Thiamine

Topics

• Aged
• Celiac Disease (chemically induced, diagnosis, physiopathology)
• Diagnosis, Differential
• Diarrhea (chemically induced, diagnosis, physiopathology)
• Humans
• Imidazoles (adverse effects, therapeutic use)
• Korsakoff Syndrome (diagnosis, physiopathology)
• Male
• Risk Factors
• Tetrazoles (adverse effects, therapeutic use)
• Thiamine (metabolism)
• Treatment Outcome
• Vitamin B Complex (metabolism)