Abstract | OBJECTIVES: METHODS: RESULTS: There was rapid improvement in ALT, particularly in the first 6 months following surgery, with statistically significant reduction in ALT at 2 months (35 vs 27 IU/L, p < 0.001). In multivariate analysis, there were significantly increased odds of ALT normalization after a %TBWL of 10-15% (odds ratio 2.49, p = 0.005). The odds of resolution increased with increasing weight loss. Triglyceride levels (odds ratio 0.59, p = 0.021) and baseline NAFLD activity score (odds ratio 0.28, p < 0.001) were also significantly related to ALT normalization. Improvements in ALT occurred prior to metabolic improvement and well before traditional ideal weight goals were reached. CONCLUSION: TRIAL REGISTRATION NUMBER: Australian Clinical Trials Registry (ACTRN12610000049077).
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Authors | Geraldine J Ooi, Paul R Burton, Lisa Doyle, John M Wentworth, Prithi S Bhathal, Ken Sikaris, Michael A Cowley, Stuart K Roberts, William Kemp, Arul Earnest, Paul E O'Brien, Wendy A Brown |
Journal | Obesity surgery
(Obes Surg)
Vol. 27
Issue 6
Pg. 1533-1542
(06 2017)
ISSN: 1708-0428 [Electronic] United States |
PMID | 27966066
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Australia
- Bariatric Surgery
- Female
- Humans
- Liver Function Tests
- Male
- Middle Aged
- Multivariate Analysis
- Non-alcoholic Fatty Liver Disease
(blood, complications, pathology)
- Obesity, Morbid
(blood, complications, pathology, surgery)
- Prospective Studies
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