Clinical predictors of positive temporal artery biopsy.

Abstract

OBJECTIVE:

We investigated the ability of known clinical signs and symptoms, as well as common laboratory tests, to correctly predict a positive temporal artery biopsy.

DESIGN:

A prospective cohort study.

PARTICIPANTS:

Consecutive patients in a tertiary referral centre undergoing temporal artery biopsy.

METHODS:

Clinical information was collected using a predesigned questionnaire. Pathology results and laboratory information were collected from digital patient records.

MAIN OUTCOME MEASURE:

The predictive value of clinical signs, symptoms, and laboratory values of a positive temporal artery biopsy.

RESULTS:

Over a 3-year period, 259 patients were enrolled and 251 patients were analyzed. Sixty-one patients had a positive biopsy. Clinical features most predictive of a positive biopsy were jaw claudication (positive likelihood ratio [LR+] 2.31) and abnormal temporal artery pulse (LR+ 2.62). Receiver operating characteristic curves generated for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelets values showed an area under curve (AUC) value of 0.71, 0.75, and 0.76, respectively. The initiation of steroids decreased the diagnostic utility of the ESR, CRP, and platelets values (AUC = 0.58, 0.61, and 0.63, respectively).

CONCLUSIONS:

A variety of clinical signs and symptoms were observed in patients referred for a temporal artery biopsy. Clinical signs and symptoms were less accurate in predicting a positive biopsy than laboratory tests. No combination of clinical signs and symptoms tested was able to predict giant cell arteritis with the certainty necessary to justify or withhold long-term steroid therapy.

• Authors: Andrew Toren, Ezekiel Weis, Vivek Patel, Bethany Monteith, Steven Gilberg, David Jordan
• Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie (Can J Ophthalmol) Vol. 51 Issue 6 Pg. 476-481 (Dec 2016) ISSN: 1715-3360 [Electronic] England
• PMID: 27938961 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Chemical References

• Glucocorticoids
• C-Reactive Protein

Topics

• Aged
• Aged, 80 and over
• Biopsy
• Blood Sedimentation
• C-Reactive Protein (metabolism)
• Cohort Studies
• False Positive Reactions
• Female
• Giant Cell Arteritis (diagnosis, drug therapy)
• Glucocorticoids (therapeutic use)
• Humans
• Intermittent Claudication (diagnosis)
• Jaw Diseases (diagnosis)
• Male
• Middle Aged
• Predictive Value of Tests
• Prospective Studies
• ROC Curve
• Sensitivity and Specificity
• Temporal Arteries (pathology)