Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.

Abstract	Discovery of new drugs for cancer treatment is an expensive and time-consuming process and the percentage of drugs reaching the clinic remains quite low.Drug repositioning refers to the identification and development of new uses for existing drugs and represents an alternative drug development strategy.In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models.By in vitro studies with five different breast cancer derived cells, we observed that combined treatment decreased proliferation (P < 0.001), mitochondrial activity (P < 0.001), migration (P < 0.001) and invasion (P < 0.001). In vivo studies in immunocompetent mice confirmed the potential of this combination in reducing tumor growth (P < 0.001) and preventing metastasis (P < 0.05).Taken together our results suggest that metformin plus propranolol combined treatment might be beneficial for triple negative breast cancer control, with no symptoms of toxicity.
Authors	María Rico, María Baglioni, Maryna Bondarenko, Nahuel Cesatti Laluce, Viviana Rozados, Nicolas André, Manon Carré, O Graciela Scharovsky, Mauricio Menacho Márquez
Journal	Oncotarget (Oncotarget) Vol. 8 Issue 2 Pg. 2874-2889 (Jan 10 2017) ISSN: 1949-2553 [Electronic] United States
PMID	27926515 (Publication Type: Journal Article)
Chemical References	Antihypertensive Agents Hypoglycemic Agents Metformin Propranolol
Topics	Animals Antihypertensive Agents (pharmacology) Apoptosis (drug effects) Breast Neoplasms (drug therapy, metabolism, mortality, pathology) Cell Line, Tumor Cell Movement (drug effects) Cell Proliferation (drug effects) Cell Survival (drug effects) Disease Models, Animal Drug Repositioning Drug Synergism Energy Metabolism Female Glycolysis Humans Hypoglycemic Agents (pharmacology) Inhibitory Concentration 50 Metformin (pharmacology) Mice Organelle Biogenesis Propranolol (pharmacology) Xenograft Model Antitumor Assays

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