The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis.

Abstract

Sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. It is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. The balance between Th1, Th17 and Regulatory T(Treg) cells controls T-cell proliferation and activation.The Th17/Treg ratio in the peripheral blood and bronchoalveolar lavage fluidis increased in patients with active sarcoidosis. Amplified IL-17A expression in granulomas and the presence of IL-17A+, IL-17A+IL-4+ and IL-17A+IFN-γ+ memory T helper cells in the circulation and BAL indicate Th17 cell involvement in granuloma induction and/or maintenance in sarcoidosis. Sarcoidosis should therefore be considered as a Th1/Th17 multisystem disorder and anti-IL-17/Th17 approaches that control and reduce IL-17Amay be an option, therefore, for the treatment of sarcoidosis.Here we provide a short overview as to the role of Th17 cells as critical cells in the pathogenesis of sarcoidosis.

• Authors: Esmaeil Mortaz, Fatemeh Rezayat, Davar Amani, Arda Kiani, Johan Garssen, Ian M Adcock, Aliakbar Velayati
• Journal: Iranian journal of allergy, asthma, and immunology (Iran J Allergy Asthma Immunol) Vol. 15 Issue 4 Pg. 334-339 (Aug 2016) ISSN: 1735-1502 [Print] Iran
• PMID: 27921415 (Publication Type: Journal Article, Review)

Chemical References

• Cytokines

Topics

• Animals
• Cytokines (immunology)
• Humans
• Sarcoidosis (immunology, pathology)
• T-Lymphocytes, Regulatory (immunology, pathology)
• Th1 Cells (immunology, pathology)
• Th17 Cells (immunology, pathology)