Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials.

Abstract

This study aimed to conduct a meta-analysis of the efficacy and safety of adjunctive minocycline for schizophrenia. Randomized controlled trials (RCTs) comparing adjunctive minocycline with placebo in patients with schizophrenia were included in the meta-analysis. Two independent investigators extracted and synthesized data. Standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) and the number-needed-to-harm (NNH) were calculated. Eight RCTs with 548 schizophrenia patient including 286 (52.2%) patients on minocycline (171.9±31.2mg/day) and 262 (47.8%) on placebo completed 18.5±13.4 weeks of treatment. Meta-analyses of Positive and Negative Syndrome Scale (PANSS) (7 RCTs with 8 treatment arms)/Brief Psychiatric Rating Scale (BPRS) (1 RCT) total score [SMD: -0.64, (95%CI: -1.02, -0.27), P=0.0008; I2=74%], positive, negative and general symptom scores [SMD: -0.69 to -0.22 (95%CI: -0.98, -0.03), P=0.02-0.00001; I2=7-63%] revealed a significant superiority of adjunctive minocycline treatment over the placebo. There was no significant difference regarding neurocognitive function, discontinuation rate and adverse drug reactions between the two groups. This meta-analysis showed that adjunctive minocycline appears to be efficacious and safe for schizophrenia. Due to significant heterogeneity, future studies with a large sample size are needed to confirm these findings.

• Authors: Ying-Qiang Xiang, Wei Zheng, Shi-Bin Wang, Xin-Hu Yang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Deanna L Kelly, Wei-Ying Xu, Yu-Tao Xiang
• Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (Eur Neuropsychopharmacol) Vol. 27 Issue 1 Pg. 8-18 (01 2017) ISSN: 1873-7862 [Electronic] Netherlands
• PMID: 27919523 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

Chemical References

• Antipsychotic Agents
• Minocycline

Topics

• Antipsychotic Agents (therapeutic use)
• Databases, Bibliographic (statistics & numerical data)
• Humans
• Minocycline (therapeutic use)
• Outcome Assessment, Health Care
• Randomized Controlled Trials as Topic
• Schizophrenia (drug therapy)