Abstract | BACKGROUND: MATERIALS AND METHODS: PubMed, ISI Web of Science, Scopus, and Google Scholar databases were searched for relevant publications until July 2014, resulting in ten relevant papers that were included in meta-analysis. Related articles were found by searching Medical Subject Heading terms of " NAFLD" in combination with "low carbohydrate". For this meta-analysis, we used mean differences and standard errors of liver function biomarkers. Summary effect and corresponding confidence interval (CI) were estimated using random effect models. Heterogeneity between studies was assessed using Cochran's Q- and I-squared tests. RESULTS: Our search led to ten eligible papers that evaluated serum ALT levels (n = 238), nine reported serum AST levels (n = 216), five reported serum GGT concentrations (n = 91), and four assessed IHLC (n = 50). LCD decreased IHLC by -11.53% (95% CI: -18.10, -4.96; I2 = 83.2%). However, the effect of LCD on liver enzymes was not significant. Mean differences for the effects of LCDs on ALT, AST, and GGT were -4.35 IU/L (95% CI: -12.91, 4.20; I2 = 87.9%), -1.44 IU/L (95% CI: -4.98, 2.10; I2 = 61.4%), and -7.85 IU/L (95% CI: -29.65, 13.96; I2 = 99.4%), respectively. CONCLUSION: LCD consumption in subjects with NAFLD led to a significant reduction in IHLC, but did not significantly affect the concentration of liver enzymes.
|
Authors | Fahimeh Haghighatdoost, Amin Salehi-Abargouei, Pamela J Surkan, Leila Azadbakht |
Journal | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
(J Res Med Sci)
Vol. 21
Pg. 53
( 2016)
ISSN: 1735-1995 [Print] India |
PMID | 27904598
(Publication Type: Review, Journal Article)
|